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The appearance of a pronucleus was used as the indicator of successful activation, suggesting that the oocyte had completed meiotic maturation and was capable of initiating embryonic development independently of fertilization

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Eur J Med Chem 46:58855893 Shiferaw WS, Akalu TY, Aynalem YA (2020) Prevalence of erectile dysfunction in patients with diabetes mellitus and its association with body mass index and glycated hemoglobin in Africa: a systematic review and meta-analysis

This is the mechanistic basis for claims about mood and neurological effects, but the chain of inference from rodent dopamine modulation to human mood benefit is long and unvalidated